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Home: Oncology Leader Commentary: Charles Loprinzi, MD

Click on the topic below for comments by Dr Charles Lorpinzi to comment on. You will also find links to related articles and clinical trials.

Clonidine for hot flashes
Physiology of hot flashes
Quality of life impact of hot flashes
Incidence of vasomotor symptoms in breast cancer patients
Soy, Vitamin E for hot flashes
Progestins for hot flashes
Estrogen for hot flashes
Dosing of progestins
Venlafaxine for hot flashes
Current trials of management of hot flashes
Soy for hot flashes

Quality of life impact of hot flashes

Interview with Neil Love, MD from Breast Cancer Update for Medical Oncologists, Program 4 2000

Play Audio Below:

The one paper I quote frequently, came out of John Hopkins, Couzi is the first author, back in Journal of Clinical Oncology several years ago, where – and again I’m going from memory here — but she interviewed, I think, 191 women who had been through the menopause and had had a history of breast cancer. And the information was that there was an astonishing number of them who had trouble with hot flashes – 60% rings a bell, but I’d have to take that with a grain of salt. Actually a similar number of women who complained of night sweats, and a similar number of women who complained of sleeping trouble. I suspect that many of those are the same women, because they’re sweating at night and waking up and then they are tired during the day, having trouble with their sleep. And, somewhere around one-third of women, a fairly high percentage of women, had tried hormone replacement therapy, despite this worry and concern that’s out there and about, and somewhere around one-third of the women said they would like to take something and would be willing to take hormone replacement therapy "if monitored closely" for what good that may or may not be we all might say, for breast cancer.

Relevant Articles:

Mammographic density changes in perimenopausal and postmenopausal women: is effect of hormone replacement therapy predictable?
Sterns, E. E. and Zee, B. Breast Cancer Research & Treatment. 59(2):125-132, 2000 Jan.

Menopausal estrogen and estrogen-progestin replacement therapy and breast cancer risk.
Schairer, C.; Lubin, J.; Troisi, R.; Sturgeon, S.; Brinton, L., and Hoover, R.. Jama: Journal of the American Medical Association. 283(4):485-491, 2000 Jan 26.

Effect of hormone replacement therapy on breast cancer risk: Estrogen versus estrogen plus progestin.
Ross, R. K.; Paganini-Hill, A.; Wan, P. C., and Pike, M. C. (Reprint available from: Ross RK Univ So Calif, Kenneth Norris Jr Comprehens Canc Ctr 1441 Eastlake Ave,Rm 8302B Los Angeles, CA 90089 USA).. Journal of the National Cancer Institute. 92(4):328-332, 2000 Feb 16.

Hormone replacement therapy in relation to risk of lobular and ductal breast carcinoma in middle-aged women
Li, C. I.; Weiss, N. S.; Stanford, J. L., and Daling, J. R.. Cancer. 88(11):2570-2577, 2000 Jun 1.

Hormone replacement therapy and breast cancer [Review].
Jacobs, H. S. Endocrine-Related Cancer. 7(1):53-61, 2000 Mar.

Biopsy confirmed benign breast disease, postmenopausal use of exogenous female hormones, and breast carcinoma risk.
Byrne, C.; Connolly, J. L.; Colditz, G. A., and Schnitt, S. J.. Cancer. 89(10):2046-2052, 2000 Nov 15.

Postmenopausal estrogens - Opposed, unopposed, or none of the above
Willett, W. C.; Colditz, G., and Stampfer, M. (Reprint available from: Willett WC Harvard Univ, Sch Publ Hlth, Dept Nutr 667 Huntington Ave Boston, MA 02115 USA).. Jama: Journal of the American Medical Association. 283(4):534-535, 2000 Jan 26. No abstract

Re: Effect of hormone replacement therapy on breast cancer risk: Estrogen versus estrogen plus progestin
Archer, D. F.; Bush, T., and Nachtigall, L. E. (Reprint available from: Nachtigall LE NYU, Sch Med, Dept Obstet & Gynecol 251 E 33rd St New York, NY 10016 USA).. Journal of the National Cancer Institute. 92(23):1950-1951, 2000 Dec 6. No abstract


Research on complementary/alternative medicine for patients with breast cancer: A review of the biomedical literature.
Jacobson, J. S.; Workman, S. B., and Kronenberg, F. Journal of Clinical Oncology. 18(3):668-683, 2000 Feb.

Evaluation of soy phytoestrogens for the treatment of hot flashes in breast cancer survivors: A North Central Cancer Treatment Group trial. Quella, S. K.; Loprinzi, C. L.; Barton, D. L.; Knost, J. A.; Sloan, J. A.; LaVasseur, B. I.; Swan, D.; Krupp, K. R.; Miller, K. D., and Novotny, P. J. Journal of Clinical Oncology. 18(5):1068-1074, 2000 Mar.

Estrogen deficiency: In search of symptom control and sexuality.
Loprinzi, C. L. and Barton, D. Journal of the National Cancer Institute. 92(13):1028-1029, 2000 Jul 5. No abstract

Managing menopausal symptoms in breast cancer survivors: Results of a randomized controlled trial.
Ganz, P. A.; Greendale, G. A.; Petersen, L.; Zibecchi, L.; Kahn, B., and Belin, T. R. Journal of the National Cancer Institute. 92(13):1054-1064, 2000 Jul 5.

Relevant Clinical Trials:

Phase III Randomized Study of Hormone Replacement Therapy in Menopausal or Perimenopausal Women with Prior Stage O-II Breast Cancer

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