1 - In view of the new data from the ATAC trial, should anastrozole now be used as adjuvant therapy for postmenopausal women with early invasive breast cancer?

2 - What is the optimal adjuvant endocrine therapy for premenopausal women with invasive breast cancer, including the role of ovarian ablation/suppression?

3 - What are the current indications for sentinel node biopsy, and how should enhanced pathology (such as IHC) be used in clinical decision-making?

4 - What is the optimal adjuvant chemotherapy for invasive breast cancer?

5 - When should postmastectomy radiation therapy be utilized?

6 - What is the optimal local and systemic therapy of local recurrence in the breast?

7 - What is the optimal method and timing for breast reconstruction after mastectomy? What factors influence the use of immediate breast reconstruction?

8 - What is the optimal local and systemic therapy of elderly women with breast cancer?

9 - What is the optimal neoadjuvant endocrine therapy and when should it be used?

10 - What is the optimal neoadjuvant chemotherapy regimen? When should it be used?

11 - What is the optimal first-line chemotherapy for women with metastases, including the role of combination regimens such as docetaxel-capecitabine?

12 - What is the optimal algorithm for assessment of tumor HER2 status?

13 - When should chemotherapy be added to trastuzumab as first-line therapy for patients with HER2-positive metastatic disease and for how long should trastuzumab be continued?

14 - What is the optimal sequencing of endocrine therapy in the metastatic setting and what is the role of fulvestrant?

15 - What is the optimal approach to breast cancer risk assessment?

16 - What is the optimal management of women at high risk for breast cancer, including the role of chemoprevention?

17 - Is there a survival benefit to screening mammography and what is the optimal screening and diagnostic algorithm?

18 - What is the role of ductal lavage in assessing breast cancer risk?

19 - What is the optimal local and systemic therapy for DCIS? Do all DCIS patients need radiation therapy? What is the optimal endocrine therapy for DCIS?

20 - What is the role of complementary or alternative medicine in the management of breast cancer?

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