Aromatase
inhibitors when adjuvant tamoxifen is contraindicated
Interview
with Neil Love, MD from Breast Cancer Update for Medical Oncologists,
Program 1 2000
Play
Audio Below:
Dr.
Locker: That question comes up, what if you have a woman who goes
on tamoxifen and can’t tolerate it, or more commonly has heard
that it’s a terrible drug, and she doesn’t want it. Would
I put her in Arimidex? And the answer was until now, I never did.
I basically tried to talk her into going on - staying on the tamoxifen.
And I think now, if I really felt that she needed an adjuvant
hormonal therapy and she was postmenopausal, she absolutely wouldn’t
take tamoxifen - I would explain to her that there is no data in
the adjuvant setting, the study is not yet reported, won’t
be for a few years, but based on the metastatic setting I would
be willing to give her anastrozole for five years. But she has to
understand that this is an off-label use and all the side effects,
etc, etc. But yes, I would do it. I am not sure that’s right,
but I would do it.
