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Home: Oncology Leader Commentary: Andrew D. Seidman, MD

Click on the topic below for comments by Dr Andrew D. Seidman to comment on. You will also find links to related articles and clinical trials.

HER-2 and selection of adjuvant therapy
Adjuvant chemotherapy for node-positive patients
Adjuvant chemotherapy plus tamoxifen in ER+ patients
Aromatase inhibitors in women with increased risk of thromboembolic complications
Tamoxifen rechallenge in the metastatic setting
Trials of adjuvant Arimidex
Aromatase inhibitors in women who cannot receive adjuvant tamoxifen
Choice of aromatase inhibitors
Chemotherapy followed by endocrine therapy for metastatic disease
Herceptin for metastatic disease
Herceptin as a single agent for metastatic disease
HER-2 assays
Trials correlating activity of Herceptin with HER 2 assay
Effect of Herceptin in "HER2-negative" patients

Choice of aromatase inhibitors

Interview with Neil Love, MD from Breast Cancer Update for Medical Oncologists, Program 3 2000

Play Audio Below:

Well, perhaps for the same reason that I drink Coke and not Pepsi, I have written very few prescriptions for letrozole and generally when you’re the first player on the block, people develop a confidence and comfort with you. Arimidex is a drug that I am entirely comfortable with, that I think is exceedingly safe and quite effective and I have no great compelling reasons to drink Pepsi so to speak.

With regards to the newest player on the block, exemestane or Aromacin, I think we just lack sufficient data to know how its going to fit into the algorithm. The uniqueness perhaps of its mechanism of action – it’s perhaps more of an activator of aromatase – is intriguing. But the relative roles of these agents as mono-therapy and certainly in combination, certainly need to be explored.

Relevant Articles:

Anastrozole versus tamoxifen as first-line therapy for advanced breast cancer in 668 postmenopausal women: Results of the tamoxifen or arimidex randomized group efficacy and tolerability study. Bonneterre, J.; Thurlimann, B.; Robertson, J. F. R.; Krzakowski, M.; Mauriac, L.; Koralewski, P.; Vergote, I.; Webster, A.; Steinberg, M., and von Euler, M. Journal of Clinical Oncology. 18(22):3748-3757, 2000 Nov 15.

Anastrozole is superior to tamoxifen as first-line therapy for advanced breast cancer in postmenopausal women: Results of a North American multicenter randomized trial.
Nabholtz, J. M.; Buzdar, A.; Pollak, M.; Harwin, W.; Burton, G.; Mangalik, A.; Steinberg, M.; Webster, A., and von Euler, M. Journal of Clinical Oncology. 18(22):3758-3767, 2000 Nov 15.

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