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Home: Oncology Leader Commentary: Andrew D. Seidman, MD

Click on the topic below for comments by Dr Andrew D. Seidman to comment on. You will also find links to related articles and clinical trials.

HER-2 and selection of adjuvant therapy
Adjuvant chemotherapy for node-positive patients
Adjuvant chemotherapy plus tamoxifen in ER+ patients
Aromatase inhibitors in women with increased risk of thromboembolic complications
Tamoxifen rechallenge in the metastatic setting
Trials of adjuvant Arimidex
Aromatase inhibitors in women who cannot receive adjuvant tamoxifen
Choice of aromatase inhibitors
Chemotherapy followed by endocrine therapy for metastatic disease
Herceptin for metastatic disease
Herceptin as a single agent for metastatic disease
HER-2 assays
Trials correlating activity of Herceptin with HER 2 assay
Effect of Herceptin in "HER2-negative" patients

Trials of adjuvant Arimidex

Interview with Neil Love, MD from Breast Cancer Update for Medical Oncologists, Program 3 2000

Play Audio Below:

I think its entirely conceivable that Arimidex will prove to be as effective as tamoxifen in the adjuvant setting and, what is more intriguing to me is this notion of combined therapy. There’s no reason to speculate antagonism between these two approaches and we – for example at Memorial – are exploring in a quite different setting, in a chemoprevention pilot, the combined use of selective estrogen receptor modulator and aromatase inactivator. So these strategies are certainly worthy of exploration, and it is to me conceivable that five or ten years from now standard adjuvant therapy will not be one antiendocrine approach but a multi-pronged approach.

Relevant Articles:

Future directions in endocrine treatment of advanced breast cancer. Bland KI. Annals of Surgical Oncology. 6(8 Suppl S):14S-16S, 1999 Dec. No Abstract

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