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Whither high-dose chemotherapy in breast cancer?

A phase II trial of docetaxel for peripheral blood stem cell mobilization for patients with breast cancer and ovarian cancerL
.Laport GG, Fleming GF, Waggoner S, Zimmerman TM, Grinblatt DL, Williams SF.

A novel pharmacological action of ET-1 to prevent the cytotoxicity of doxorubicin in cardiomyocytes.
Suzuki T, Miyauchi T. Am J Physiol Regul Integr Comp Physiol. 2001;280:R1399-406.

Extracellularly tumor-activated prodrugs for the selective chemotherapy of cancer: application to doxorubicin and preliminary in vitro and in vivo studies.
Trouet A, Passioukov A, Van derpoorten K, et al. Cancer Res. 2001;61:2843-6.

Gene expression and amplification in breast carcinoma cells with intrinsic and acquired doxorubicin resistance.
Turton NJ, Judah DJ, Riley J, et al. Oncogene. 2001;20:1300-6.

Reduction of Paclitaxel-induced Peripheral Neuropathy with Glutamine.
Vahdat L, Papadopoulos K, Lange D, et al. Clin Cancer Res. 2001;7:1192-1197.

Reduction of Paclitaxel-induced Peripheral Neuropathy with Glutamine.
Vahdat L, Papadopoulos K, Lange D, et al. Clin Cancer Res. 2001;7:1192-1197.

A new prodrug of paclitaxel: synthesis of Protaxel
Seligson AL, Terry RC, Bressi JC, Douglass III JG, Sovak M.. Anticancer Drugs. 2001;12:305-13.

Hyperthermic enhancement of the apoptotic and antiproliferative activities of paclitaxel.
Othman T, Goto S, Lee JB, Taimura A, Matsumoto T, Kosaka M. Pharmacology.
2001;62:208-12.

Benefit of a high-dose epirubicin regimen in adjuvant chemotherapy for node-positive breast cancer patients with poor prognostic factors: 5-year follow-up results of French adjuvant study group 05 randomized trial.
Adenis A, Bonneterre J, Bonneterre ME, et al. Journal of Clinical Oncology. 19(3):602-611, 2001 Feb 1.

A critique of the eleven randomised trials of high-dose chemotherapy for breast cancer [Review].
Antman KH. European Journal of Cancer. 37(2):173-179, 2001 Jan.

Infectious complications the year after autologous bone marrow transplantation or peripheral stem cell transplantation for treatment of breast cancer.
Barton TD, Collis T, Stadtmauer E, Schuster MG. Clinical Infectious Diseases. 32(3):391-395, 2001 Feb 1.

High-dose thiotepa and melphalan with hemopoietic progenitor support following induction therapy with epirubicin-paclitaxel-containing regimens in metastatic breast cancer (MBC).
Bengala C, Pazzagli I, Innocenti F, et al. Annals of Oncology. 12(1):69-74, 2001 Jan.

Low infectious morbidity after intensive chemotherapy and autologous peripheral blood progenitor cell transplantation in the outpatient setting for women with breast cancer.
Chandrasekar PH, Abraham OC, Klein J, et al. Clinical Infectious Diseases. 32(4):546-551, 2001 Feb 15.

A short course of induction chemotherapy followed by two cycles of high-dose chemotherapy with stem cell rescue for chemotherapy naive metastatic breast cancer.
Elias AD, Richardson P, Avigan D, et al. Bone Marrow Transplantation. 27(3):269-278, 2001 Feb.

Use of granulocyte colony-stimulating factor after high-dose chemotherapy and autologous peripheral blood stem cell transplantation - What is the optimal timing?
Ener RA, Meglathery SB, Cuhaci B, et al. American Journal of Clinical Oncology-Cancer Clinical Trials. 24(1):19-25, 2001 Feb.

Hematopoietic recovery of ex vivo perfusion culture expanded bone marrow and unexpanded peripheral blood progenitors after myeloablative chemotherapy.
Engelhardt M, Douville J, Behringer D, et al. Bone Marrow Transplantation. 27(3):249-259, 2001 Feb.

Intensification of adjuvant chemotherapy: 5-year results of a randomized trial comparing conventional doxorubicin and cyclophosphamide with high-dose mitoxantrone and cyclophosphamide with filgrastim in operable breast cancer with 10 or more involved axillary nodes.
Fumoleau P, Chauvin F, Namer M, et al. Journal of Clinical Oncology. 19(3):612-620, 2001 Feb 1.

A randomized trial of amifostine in patients with high-dose VIC chemotherapy plus autologous blood stem cell transplanation.
Hartmann JT, von Vangerow A, Fels LM, et al. British Journal of Cancer. 84(3):313-320, 2001 Feb 2.

Population pharmacokinetics of thioTEPA and its active metabolite TEPA in patients undergoing high-dose chemotherapy.
Huitema ADR, Mathot RAA, Tibben MM, Schellens JHM, Rodenhuis S, Beijnen JH. British Journal of Clinical Pharmacology. 51(1):61-70, 2001 Jan.

Modulation of graft-versus-tumor effects in a murine allogeneic bone marrow transplantation model by tumor-derived transforming growth factor-beta 1.
Kummar S, Ishii A, Yang HK, Venzon DJ, Kim SJ, Gress RE. Biology of Blood & Marrow Transplantation. 7(1):25-30, 2001.

Whither high-dose chemotherapy in breast cancer? [Review].
Mayer A, Earl H. Breast Cancer Research. 3(1):8-10, 2001.

The pharmacokinetics and pharmacodynamics of high-dose paclitaxel monotherapy (825 mg/m(2) continuous infusion over 24 h) with hematopoietic support in women with metastatic breast cancer.
Papadopoulos KP, Egorin MJ, Huang M, et al. Cancer Chemotherapy & Pharmacology. 47(1):45-50, 2001 Jan.

High-dose chemotherapy in breast cancer - interpretation of the randomized trials.
Rodenhuis S. Anti-Cancer Drugs. 12(2):85-88, 2001 Feb.

Prognostic significance of the immunocytochemical detection of contaminating tumor cells (CTC) in apheresis products of patients with high-risk breast cancer treated with high-dose chemotherapy and stem cell transplantation.
Solano C, Badia B, Lluch A, et al. Bone Marrow Transplantation. 27(3):287-293, 2001 Feb.

Pilot trial of interleukin-1 with granulocyte colony-stimulating factor for the mobilization of progenitor cells in advanced breast cancer patients undergoing high-dose chemotherapy: Expansion of immune effectors within the stem-cell graft and post-stem-cell infusion.
Sosman JA, Stiff P, Moss SM, et al. Journal of Clinical Oncology. 19(3):634-644, 2001 Feb 1.

Preoperative high-dose chemotherapy with peripheral blood stem cell support as a primary management of locally advanced breast cancer.
Wang X, Tang J, Wu J, et al. Bone Marrow Transplantation. 27(3):345-346, 2001 Feb.

Clinical Impacts of Tumor Cell Contamination of Hematopoietic Stem Cell Products in Metastatic Breast Cancer Patients undergoing Autologous Peripheral Blood Stem Cell Transplantation: Multicenter Trial.
Ahn MJ, Noh YH, Lee YS, et al. J Korean Med Sci. 2001;16:175-82.

Randomized trials of high dose chemotherapy for breast cancer.
Antman KH. Biochim Biophys Acta. 2001;1471:M89-98.

Kinetics of PBPC mobilization by cyclophosphamide, as compared with that by epirubicin/paclitaxel followed by G-CSF support: implications for optimal timing of PBPC harvest.
Dettke M, Greinix HT, Kalhs P, Kuhrer I, Worel N, Hocker P. Transfusion.
2001;41:681-6.

A phase II trial of docetaxel for peripheral blood stem cell mobilization for patients with breast cancer and ovarian cancer.
Laport GG, Fleming GF, Waggoner S, Zimmerman TM, Grinblatt DL, Williams SF. Bone Marrow Transplant. 2001;27:677-81.

 

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