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Miscellaneous Topics
Antiestrogens, Tamoxifen
Aromatase Inhibitors

Faslodex® (Fulvestrant, ICI182180)
Ovarian Ablation/Suppression
Estrogen/Progesterone Receptors

Miscellaneous articles

Digitized mammography: a clinical trial of postmenopausal women randomly assigned to receive raloxifene, estrogen, or placebo.
Freedman M, San Martin J, O'Gorman J, et al. J Natl Cancer Inst. 93(1):51-56, 2001 Jan 3.

Silencing and reactivation of the selective estrogen receptor modulator-estrogen receptor alpha complex.
Liu H, Lee ES, Deb Los Reyes A, Zapf JW, Jordan VC. Cancer Res. 2001;61:3632-9.

Tumor variants by hormone receptor expression in white patients with node-negative breast cancer from the surveillance, epidemiology, and end results database.
Anderson WF, Chu KC, Chatterjee N, Brawley O, Brinton LA. Journal of Clinical Oncology. 19(1):18-27, 2001 Jan 1.

Estrogen and antiestrogen actions on transforming growth factorbeta (Tgfbeta) in normal human breast epithelial (HBE) cells.
Malet C, Fibleuil F, Mestayer C, Mowszowicz I, Kuttenn F. Mol Cell Endocrinol. 2001;174:21-30.

Antiestrogens, Tamoxifen

Scottish adjuvant Tamoxifen trial: a randomized study updated to 15 years.
Stewart HJ, Prescott RJ, Forrest AP. J Natl Cancer Inst. 2001;93:456-62.

Mechanism of lower genotoxicity of toremifene compared with Tamoxifen.
Shibutani S, Ravindernath A, Terashima I, et al. Cancer Res. 2001;61:3925-31.

Preliminary assessment of cognitive function in breast cancer patients treated with Tamoxifen.
Paganini-Hill A, Clark LJ. Breast Cancer Res Treat. 2001;64:165-76.

Understanding the genotoxicity of Tamoxifen?
Phillips DH. Carcinogenesis. 2001;22:839-849.

Tamoxifen-induced hypertriglyceridemia in association with diabetes mellitus.
Milionis HJ, Liberopoulos EN, Elisaf MS. Diabetes Metab. 2001;27:160-3.

Prospective study on gynaecological effects of two antioestrogens Tamoxifen and toremifene in postmenopausal women.
Marttunen MB, Cacciatore B, Hietanen P, et alBr J Cancer. 2001;84:897-902.

Interaction of phytoestrogens with estrogen receptors alpha and beta.
Morito K, Hirose T, Kinjo J, et al. Biol Pharm Bull. 2001;24:351-6.

Phase I study of a third-generation selective estrogen receptor modulator, LY353381.HCL, in metastatic breast cancer.
Munster PN, Buzdar A, Dhingra K, et al. J Clin Oncol. 2001;19:2002-9.

Flexible estrogen receptor modulators: design, synthesis, and antagonistic effects in human MCF-7 breast cancer cells.
Meegan MJ, Hughes RB, Lloyd DG, Williams DC, Zisterer DM. J Med Chem. 2001;44:1072-84.

Tamoxifen-induced antitumorigenic/antiestrogenic action synergized by a selective aryl hydrocarbon receptor modulator.
McDougal A, Wormke M, Calvin J, Safe S. Cancer Res. 2001;61:3902-7.

Tamoxifen and chemotherapy for axillary node-negative, estrogen receptor-negative breast cancer: Findings from National Surgical Adjuvant Breast and Bowel Project B-23.
Fisher B, Anderson S, Tan-Chiu E, et al. Journal of Clinical Oncology. 19(4):931-942, 2001 Feb 15.

Adjuvant Tamoxifen: Predictors of use, side effects, and discontinuation in older women.
Demissie S, Silliman RA, Lash TL. Journal of Clinical Oncology. 19(2):322-328, 2001 Jan 15.

Tamoxifen-failed male breast cancer with a high level of circulating estrogen: Report of a case.
Takei H, Iino Y, Horiguchi J, et al.  Surgery Today-The Japanese Journal of Surgery. 31(2):149-151, 2001.

Phosphatidylinositol 3-kinase/AKT-mediated activation of estrogen receptor alpha: a new model for anti-estrogen resistance.
Campbell RA, Bhat-Nakshatri P, Patel NM, Constantinidou D, Ali S, Nakshatri H. J Biol Chem. 2001;276:9817-24.

Circumventing Tamoxifen resistance in breast cancers using antiestrogens that induce unique conformational changes in the estrogen receptor.
Connor CE, Norris JD, Broadwater G, et al. Cancer Res. 2001;61:2917-22.

Five versus more than five years of Tamoxifen for lymph node-negative breast cancer: updated findings from the National Surgical Adjuvant Breast and Bowel Project B-14 randomized trial.
Fisher B, Dignam J, Bryant J, Wolmark N. J Natl Cancer Inst. 2001;93:684-90.

Phase I clinical trial of alitretinoin and Tamoxifen in breast cancer patients: toxicity, pharmacokinetic, and biomarker evaluations.
Lawrence JA, Adamson PC, Caruso R, et al. J Clin Oncol. 2001;19:2754-63.

Tamoxifen treatment and gynecologic side effects: a review.
Mourits MJ, De Vries EG, Willemse PH, Ten Hoor KA, Hollema H, Van der Zee AG.
Obstet Gynecol. 2001;97:855-66.

Aromatase Inhibitors

Superior efficacy of letrozole versus Tamoxifen as first-line therapy for postmenopausal women with advanced breast cancer: results of a phase iii study of the international letrozole breast cancer group.
Mouridsen H, Gershanovich M, Sun Y, et al. J Clin Oncol. 2001;19:2596-606.

Pharmacokinetics and metabolism of formestane in breast cancer patients.
Lonning PE, Geisler J, Johannessen DC, et al. J Steroid Biochem Mol Biol. 2001;77:39-47.

Aromatase inhibitors in the treatment and prevention of breast cancer [Review].
Goss PE, Strasser K. Journal of Clinical Oncology. 19(3):881-894, 2001 Feb 1.

Efficacy of levormeloxifene in the prevention of postmenopausal bone loss and on the lipid profile compared to low dose hormone replacement therapy.
Alexandersen P, Riis BJ, Stakkestad JA, Delmas PD, Christiansen C. Journal of Clinical Endocrinology & Metabolism. 86(2):755-760, 2001 Feb.

Influence of neoadjuvant anastrozole (arimidex) on intratumoral estrogen levels and proliferation markers in patients with locally advanced breast cancer.
Geisler J, Detre S, Berntsen H, et al. Clin Cancer Res. 2001;7:1230-6.

Faslodex® (fulvestrant, ICI182180): An estrogen receptor downregulator

No new publications

 

Ovarian ablation/suppression

No new publications

 

Estrogen/progesterone receptors

No new publications

 

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