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Home: Oncology Leader Commentary: Aman Buzdar, MD

Click on the topic below for comments by Dr Aman Buzdar to comment on. You will also find links to related articles and clinical trials.

Arimidex as first-line therapy
Toxicity profile of Arimidex
Choice of first-line endocrine therapy for postmenopausal patients
Neoadjuvant anastrozole
ATAC adjuvant trial: Arimidex vs Tamoxifen vs the Combination
Adjuvant tamoxifen in low-risk patients
Adjuvant tamoxifen in premenopausal patients
Adjuvant tamoxifen in patients with DCIS

Adjuvant tamoxifen in patients with DCIS

Interview with Neil Love, MD from Breast Cancer Update for Medical Oncologists, Program 1 2000

Play Audio Below:

Dr. Buzdar: The data is very strong in NSABP, because there was very similar supportive data from the DCIS what you saw in P1, what you see from the overview. I think that’s real, I think these patients should be offered tamoxifen, and to me it’s not an issue. I think it is strong evidence that in that subset of patients we should consider tamoxifen and offer it to the woman.

Dr. Love: And in that situation are you focused just as much on the 2nd primary as you are on local recurrence?

Dr. Buzdar: The benefit as you saw in the data it is both in the ipsilateral recurrent and contralateral in the primaries, so both are substantially reduced.

Relevant Articles:

Treatment selection in ductal carcinoma in situ.
Morrow, M. and Schnitt, S. J. JAMA: Journal of the American Medical Association. 283(4):453-455, 2000 Jan 26.

Outcomes and factors impacting local recurrence of ductal carcinoma in situ.
Weng, E. Y.; Juillard, G. J. F.; Parker, R. G.; Chang, H. R., and Gornbein, J. A. Cancer. 88(7):1643-1649, 2000 Apr 1.

Relevant Clinical Trials:

Phase III Randomized Study of Tamoxifen With or Without Radiotherapy in Women With Ductal Carcinoma In Situ (DCIS) of the Breast

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