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Home: Oncology Leader Commentary: Aman Buzdar, MD

Click on the topic below for comments by Dr Aman Buzdar to comment on. You will also find links to related articles and clinical trials.

Arimidex as first-line therapy
Toxicity profile of Arimidex
Choice of first-line endocrine therapy for postmenopausal patients
Neoadjuvant anastrozole
ATAC adjuvant trial: Arimidex vs Tamoxifen vs the Combination
Adjuvant tamoxifen in low-risk patients
Adjuvant tamoxifen in premenopausal patients
Adjuvant tamoxifen in patients with DCIS

Adjuvant tamoxifen in premenopausal patients

Interview with Neil Love, MD from Breast Cancer Update for Medical Oncologists, Program 1 2000

Play Audio Below:

That was one of the major strong evidence of the overview, and I think it had a lot of impact, especially in this country. Because there are a lot of skepticism including in my own mind that tamoxifen does not add anything in premenopausal woman who are ER-positive. But the data is quite convincing now that in the ER-positive patients who are premenopausal tamoxifen in the adjuvant setting does reduce the risk of recurrence and does have a favorable impact on the survival if the drug is given for five years.

Relevant Articles:

Selective estrogen receptor modulators: Structure, function, and clinical use [Review].
Osborne, C. K. and Fuqua, S. A. W. Journal of Clinical Oncology. 18(17):3172-3186, 2000 Sep.

Relevant Clinical Trials:

Study of Tamoxifen in the Prevention of Skeletal and Cardiovascular Morbidity of Adjuvant Chemotherapy in Premenopausal Women With Stage I or II Breast Cancer

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