Dr.
Dixon: If we define responses greater than a 50% reduction in tumor
volume, we are seeing between a 80% and 90% response rate with the
aromatase inhibitors, which is pretty impressive really. And of
the two series we’ve treated with letrozole and anastrozole
it’s only 48 patients, but only one patient has had any significant
increase in tumor size.
Dr.
Love: And what overall volume reduction are you seeing?
Dr.
Dixon: With one milligram of anastrozole with three months treatment,
we saw an 80% reduction in tumor volume.
Relevant
Articles:
ARIMIDEX'
as Neoadjuvant Therapy Causes Large Reductions in Tumour Volume
in Postmenopausal Women with Large Operable Breast Cancers. (Meeting
abstract). Dixon Michael. Renshaw L. Bellamy C. Cameron DA.
Miller WR. Proc Annu Meet Am Soc Clin Oncol. 18:A345, 1999.
Neoadjuvant
Treatment with Anastrozole ('ARIMIDEX') Causes Profound Suppression
of Intra-Tumor Estrogen Levels (Meeting abstract). Geisler Jurge.
Bernsten H. Ottestad L. Lindtjorn B. Dowsett M. Lonning PE. Proc
Annu Meet Am Soc Clin Oncol 18:A311, 1999.
