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Home: Oncology Leader Commentary: Nancy E. Davidson, MD

Click on the topic below for comments by Dr Nancy E. Davidson to comment on. You will also find links to related articles and clinical trials.

Intergroup study of adjuvant ovarian suppression
Main results of Intergroup adjuvant premenopausal study
Management of node-postive, ER+ premenopausal patients
Ovarian ablation after chemotherapy in patients who continue to menstrate
Harvey study of estrogen receptors
Use of adjuvant tamoxifen
Choice of aromatase inhibitor
Management of metastatic disease in younger women
Combined endocrine therapy in premenopausal patients with metastases
Tamoxifen for patients with DCIS
Psychosocial issue in young breast cancer patients
Risk for recurrence and use of cytotoxic therapy
Use of prognostic factors in invasive breast cancer

Choice of aromatase inhibitor

Interview with Neil Love, MD from Breast Cancer Update for Medical Oncologists, Program 3 2000

Play Audio Below:

I actually, personally, use anastrozole. And, I’ll be real honest, its because they were the first ones on the block I got used to using it. When letrozole came out we actually looked in our pharmacy because I said I’d use the cheaper one, whichever it was, and there was no difference in cost between the two of them. It will be interesting to see what happens with exemestane now that it’s come on. I know there are reported to be responses in women who have failed more traditional aromatase inhibitors. But it's wonderful to have those drugs to choose from now and it has allowed me to just discard some other things.

Relevant Articles:

Anastrozole versus tamoxifen as first-line therapy for advanced breast cancer in 668 postmenopausal women: Results of the tamoxifen or arimidex randomized group efficacy and tolerability study.
Bonneterre, J.; Thurlimann, B.; Robertson, J. F. R.; Krzakowski, M.; Mauriac, L.; Koralewski, P.; Vergote, I.; Webster, A.; Steinberg, M., and von Euler, M. Journal of Clinical Oncology. 18(22):3748-3757, 2000 Nov 15.

Anastrozole is superior to tamoxifen as first-line therapy for advanced breast cancer in postmenopausal women: Results of a North American multicenter randomized trial.
Nabholtz, J. M.; Buzdar, A.; Pollak, M.; Harwin, W.; Burton, G.; Mangalik, A.; Steinberg, M.; Webster, A., and von Euler, M. Journal of Clinical Oncology. 18(22):3758-3767, 2000 Nov 15.

Critique of survival update analysis from two phase III anastrozole clinical trials. Buzdar, A. U.; Wood; Wolter; Vogel; Bland, and Ravdin. Annals of Surgical Oncology. 6(8 Suppl S):8S-11S, 1999 Dec. No abstract

Static disease on anastrozole provides similar benefit as objective response in patients with advanced breast cancer.
Robertson, J. F. R.; Howell, A.; Buzdar, A.; von Euler, M., and Lee, D.. Breast Cancer Research & Treatment. 58(2):157-162, 1999 Nov.

ARIMIDEX' as Neoadjuvant Therapy Causes Large Reductions in

Tumour Volume in Postmenopausal Women with Large Operable Breast Cancers.
(Meeting abstract). Dixon Michael. Renshaw L. Bellamy C. Cameron DA. Miller WR. Proc Annu Meet Am Soc Clin Oncol. 18:A345, 1999. No Abstract.

Neoadjuvant Treatment with Anastrozole ('ARIMIDEX') Causes Profound Suppression of Intra-Tumor Estrogen Levels (Meeting abstract).
Geisler Jurge. Bernsten H. Ottestad L. Lindtjorn B. Dowsett M. Lonning PE. Proc Annu Meet Am Soc Clin Oncol 18:A311, 1999. No Abstract.

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