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Home: Oncology Leader Commentary: Nancy E. Davidson, MD

Click on the topic below for comments by Dr Nancy E. Davidson to comment on. You will also find links to related articles and clinical trials.

Intergroup study of adjuvant ovarian suppression
Main results of Intergroup adjuvant premenopausal study
Management of node-postive, ER+ premenopausal patients
Ovarian ablation after chemotherapy in patients who continue to menstrate
Harvey study of estrogen receptors
Use of adjuvant tamoxifen
Choice of aromatase inhibitor
Management of metastatic disease in younger women
Combined endocrine therapy in premenopausal patients with metastases
Tamoxifen for patients with DCIS
Psychosocial issue in young breast cancer patients
Risk for recurrence and use of cytotoxic therapy
Use of prognostic factors in invasive breast cancer

Risk for recurrence and use of cytotoxic therapy

Interview with Neil Love, MD from Breast Cancer Update for Medical Oncologists, Program 3 2000

Play Audio Below:

Dr. Davidson: I don’t give it to virtually anybody whose tumor is under a centimeter, which is a fair number actually in this day and age with mammographic screening. And between one and two centimeters – particularly as she ages – it’s an agonizing discussion. I would routinely give it over two centimeters. I think about it with every woman. We’re only talking about receptor-positive patients here because of course, if they’re receptor negative that’s a different discussion. But, between one and two centimeters, I would say we spend a lot of time agonizing over it, and probably the younger you are and the closer you are to two centimeters, the more likely we’ll go with the chemo. But, you know, there are a lot of 1.1 centimeter tumors out there where we make the decision that, in the end, it doesn’t seem like it’s a worthwhile trade-off.

Dr. Love: Well, particularly if you have the option of a hormonal intervention.

Dr. Davidson: Oh yeah, with the tamoxifen. I mean, if it’s a 1.1 centimeter, receptor-negative breast cancer, unless somebody is not a chemotherapy candidate or is a bit older, I don’t think that I would have much discussion not doing it.

Relevant Articles:

Framing of outcome and probability of recurrence: breast cancer patients' choice of adjuvant chemotherapy (ACT) in hypothetical patient scenarios.
Zimmermann C, Baldo C, Molino A. Breast Cancer Res Treat. 2000 Mar;60(1):9-14.

What threshold for adjuvant therapy in older breast cancer patients?
Extermann M, Balducci L, Lyman GH. J Clin Oncol. 2000 Apr;18(8):1709-17.

Treating young patients with breast cancer. The evidence suggests that all should be treated with adjuvant therapy.
Dixon JM, Hortobagyi G. BMJ. 2000 Feb 19;320(7233):457-8.

Value of estrogenic recruitment before chemotherapy: first randomized trial in primary breast cancer. Bontenbal M, van Putten WL, Burghouts JT, Baggen MG, Ras GJ, Stiegelis WF, Beudeker M, Janssen JT, Braun JJ, van der Linden GH, van der Velden PC, van Geel AN, Helle P, Leisink M, Foekens JA, Klijn JG. J Clin Oncol. 2000 Feb;18(4):734-42.

Locoregional failure 10 years after mastectomy and adjuvant chemotherapy with or without tamoxifen without irradiation: experience of the Eastern Cooperative Oncology Group.
Recht A, Gray R, Davidson NE, Fowble BL, Solin LJ, Cummings FJ, Falkson G, Falkson HC, Taylor SG, Tormey DC. J Clin Oncol. 1999 Jun;17(6):1689-700.

Relevant Clinical Trials:

NCI HIGH-PRIORITY CLINICAL TRIAL--Phase III Randomized Study of Intensive Sequential Doxorubicin, Paclitaxel, and Cyclophosphamide Versus Doxorubicin and Cyclophosphamide Followed By STAMP I or STAMP V Combination Chemotherapy With Autologous Stem Cell Rescue in Women With Primary Breast Cancer and At Least 4 Involved Axillary Lymph Nodes

Phase III Randomized Study of Adjuvant Doxorubicin and Cyclophosphamide Followed by Docetaxel Versus Doxorubicin and Docetaxel Versus Doxorubicin, Docetaxel, and Cyclophosphamide in Women With Breast Cancer and Positive Axillary Nodes

Phase III Randomized Study of Doxorubicin and Cyclophosphamide Followed by Paclitaxel With or Without Trastuzumab (Herceptin) in Women With Node Positive Breast Cancer That Overexpresses HER2

Phase III Randomized Study of Doxorubicin Plus Cyclophosphamide Followed by Paclitaxel With or Without Trastuzumab (Herceptin) in Patients With HER-2 Overexpressing Breast Cancer

Phase III Randomized Study of Adjuvant Clodronate With or Without Systemic Chemotherapy and/or Tamoxifen in Women With Early-Stage Breast Cancer

Phase III Study of Prolonged Adjuvant Tamoxifen for Curatively Treated Breast Cancer

Phase III Randomized Adjuvant Study of Tamoxifen in Women with Early Breast Cancer

Phase III Randomized Study of Letrozole Versus Placebo in Women with Resected Breast Cancer After Completion of Treatment with Adjuvant Tamoxifen

Phase III Study of the Effect of Menstrual Cycle Timing With Breast Surgery on Prognosis in Premenopausal Women With Stage I, II, or III Breast Cancer

Correlation of Menstrual Cycle Phase at the Time of Surgery with Disease-Free Survival in Women with Stage I/II Breast Cancer

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