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Home: Oncology Leader Commentary: Nancy E. Davidson, MD

Click on the topic below for comments by Dr Nancy E. Davidson to comment on. You will also find links to related articles and clinical trials.

Intergroup study of adjuvant ovarian suppression
Main results of Intergroup adjuvant premenopausal study
Management of node-postive, ER+ premenopausal patients
Ovarian ablation after chemotherapy in patients who continue to menstrate
Harvey study of estrogen receptors
Use of adjuvant tamoxifen
Choice of aromatase inhibitor
Management of metastatic disease in younger women
Combined endocrine therapy in premenopausal patients with metastases
Tamoxifen for patients with DCIS
Psychosocial issue in young breast cancer patients
Risk for recurrence and use of cytotoxic therapy
Use of prognostic factors in invasive breast cancer

Tamoxifen for patients with DCIS

Interview with Neil Love, MD from Breast Cancer Update for Medical Oncologists, Program 3 2000

Play Audio Below:

They all come in for medical oncology consultation to talk a little bit about tamoxifen or not. I’m finding in my practice it's about a 50/50 hit rate for tamoxifen. About half the women who come in to see me come to the end of those numbers – because it's pretty easy to share with them the NSABP trial – and they look at it and they say, "Yep, sounds good to me. I want to go for it. I want to be very aggressive in my breast cancer management here." And the other half look at it and think that the numbers look very small and I guess, in that, they’re probably very similar to women who come in for true prevention discussions. The folks who are particularly uninterested are those who had a mastectomy for treatment of their DCIS because they realize it has no impact on treatment of their known malignancy, and then they sit around and think about how important it is to them for the contralateral breast. Lots of times what people do is they try it for a while. You know, if they’re very worried about toxicity issues, I find that anticipation is worse than the experience for a lot of women. And it seems like they’re awfully worried about going on it and then, when they come back three months into it, it isn’t perfect, but the side effect profile is sometimes not what they were concerned about.

Relevant Articles:

Treatment selection in ductal carcinoma in situ.
Morrow, M. and Schnitt, S. J. (Reprint available from: Morrow M NW Mem Hosp, Lynn Sage Comprehens Breast Ctr 251 E Huron St,Galter 13-174 Chicago, IL 60611 USA). JAMA: Journal of the American Medical Association. 283(4):453-455, 2000 Jan 26.

Outcomes and factors impacting local recurrence of ductal carcinoma in situ.
Lagios, M. D. and Silverstein, M. J. (Reprint available from: Lagios MD St Marys Med Ctr, Breast Canc Consultat Serv San Francisco, CA 94143 USA).. Cancer. 89(11):2323-2324, 2000 Dec 1.

Outcomes and factors impacting local recurrence of ductal carcinoma in situ.
Weng, E. Y.; Juillard, G. J. F.; Parker, R. G.; Chang, H. R., and Gornbein, J. A. Cancer. 88(7):1643-1649, 2000 Apr 1

Relevant Clinical Trials:

Phase III Randomized Study of Tamoxifen With or Without Radiotherapy in Women With Ductal Carcinoma In Situ (DCIS) of the Breast

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