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Burstein HJ et al. Efficacy of pegfilgrastim and darbepoetin alfa as hematopoietic
support for dose-dense every-2-week adjuvant breast cancer chemotherapy. J Clin Oncol 2005;23(33):8340-7. Abstract

Citron ML et al. Randomized trial of dose-dense versus conventionally scheduled and sequential versus concurrent combination chemotherapy as postoperative adjuvant treatment of node-positive primary breast cancer: First report of Intergroup Trial C9741/Cancer and Leukemia Group B Trial 9741. J Clin Oncol 2003;21(8):1431-9. Abstract

Dang C et al. Updated cardiac safety results of dose-dense (DD) doxorubicin and cyclophosphamide (AC) followed by paclitaxel (T) with trastuzumab (H) in HER2/neu overexpressed/amplified breast cancer (BCA). Proc ASCO 2006;Abstract 582.

Dang C et al. Preliminary cardiac safety results of dose-dense (DD) doxorubicin and
cyclophosphamide (AC) followed by paclitaxel (T) with trastuzumab (H) in HER2/
neu overexpressed/amplified breast cancer (BCA). Poster. San Antonio Breast Cancer
Symposium 2005;Abstract 2041.

Hudis C et al. Five year follow-up of INT C9741: Dose-dense (DD) chemotherapy (CRx) is safe and effective. San Antonio Breast Cancer Symposium 2005;Abstract 41.

Minn AJ et al. Genes that mediate breast cancer metastasis to lung. Nature
2005;436(7050):518-24. Abstract

Norton L, Massagué J. Is cancer a disease of self-seeding? Nat Med 2006;12(8):875-2006;12(8):875-8, copyright 2006. No abstract available

Norton L. Conceptual and practical implications of breast tissue geometry: Toward a more effective, less toxic therapy. Oncologist 2005;10(6):370-81. Abstract

 

 

 

 

 

 

 

 

 

 

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Editor’s Note:
A tale of two trials

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Larry Norton, MD
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