STATEMENT OF NEED/TARGET AUDIENCE

Breast cancer is one of the most rapidly evolving fields in medical oncology. Published results from ongoing clinical trials lead to the continuous emergence of new therapeutic agents and changes in the indications for existing treatments. In order to offer optimal patient care — including the option of clinical trial participation — the practicing clinician must be well informed of these advances. To bridge the gap between research and patient care, Breast Cancer Update uses one-on-one discussions with leading oncology investigators. By providing access to the latest research developments and expert perspectives, this CME program assists medical oncologists, hematologists and hematology-oncology fellows with the formulation of up-to-date clinical management strategies.

LEARNING OBJECTIVES

• Evaluate the clinical implications of emerging clinical trial data in breast cancer treatment, and incorporate these findings into management strategies in the neoadjuvant, adjuvant and metastatic settings.
• Counsel appropriately selected patients about the availability of ongoing clinical trials.
• Select medical and surgical management regimens for early breast cancer based on key clinical and pathological risk factors.
• Assess existing data and emerging research on the optimal duration and sequence of adjuvant endocrine therapy for patients who are postmenopausal with ER-positive breast cancer, and apply this evidence to routine patient care decisions.
• Implement an algorithm for HER2 testing and selection of evidence-based treatment strategies for patients with early and advanced HER2-positive breast cancer.
• Evaluate the utility of tissue-based genomic assays for therapeutic decision-making and, when applicable, use these in the selection of individualized treatment regimens for patients with early breast cancer.
• Review the emerging data on various adjuvant chemotherapy approaches, including modified doses and schedules and the use of taxanes, and explain the absolute risks and benefits of these regimens to patients.
• Appraise emerging data on novel biologic and molecular-targeted therapies with clinical activity in breast cancer, and determine how these should be incorporated into the treatment algorithm for appropriate patients with metastatic disease, including patients with triple-negative tumors.
• Integrate psychosocial support, optimal patient-physician communication strategies and evidence-based clinical decision-making into a comprehensive approach to patient care.

PURPOSE OF THIS ISSUE OF BREAST CANCER UPDATE

The purpose of Issue 3 of Breast Cancer Update is to support the learning objectives by offering the perspectives of Drs Forbes, Gralow, Hayes, Perez, Robert, Robertson and Wolff on the integration of emerging clinical research data into the management of breast cancer.

ACCREDITATION STATEMENT

Research To Practice is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.

CREDIT DESIGNATION STATEMENT

Research To Practice designates this educational activity for a maximum of 4.5 AMA PRA Category 1 Credit(s)™. Physicians should only claim credit commensurate with the extent of their participation in the activity.

HOW TO USE THIS CME ACTIVITY

This CME activity contains both audio and print components. To receive credit, the participant should listen to the CDs, review the Internet content and complete the Post-test and Educational Assessment located at www.BreastCancerUpdate.com/CME. www.BreastCancerUpdate.com contains edited comments, clinical trial schemas, graphics and references that supplement the audio program, as well as links to relevant full-text articles, abstracts, trial information and other web resources.

This program is supported by educational grants from Abraxis BioScience, AstraZeneca Pharmaceuticals LP, Genentech BioOncology, Genomic Health Inc, GlaxoSmithKline, Novartis Pharmaceuticals Corporation, Roche Laboratories Inc and Sanofi-Aventis.

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EDITOR'S NOTE
Bev, BETH, BEATRICE and the next big moment in oncology
research: NSABP-C-08
Neil Love, MD
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INTERVIEWS
Daniel F Hayes, MD
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John F Forbes, MD
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Julie R Gralow, MD
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John F R Robertson, MB, ChB, BSc, MD
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Roundtable Discussion
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Breast Cancer Update:
A CME Audio Series and Activity

Faculty Disclosures

Editor's Office